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KMID : 0869619980150040530
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Journal of Korean Society of Hospital Pharmacists
1998 Volume.15 No. 4 p.530 ~ p.534
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Weight Loss of Tablet by Operating Automatic Tablet Counter
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홍혜정/Hong, Hye Jung
이미경/신숭휘/주수만/김남재/송보완/김종우/Lee, Mi Kyung/Shin, Soong Hui/Joo, Soo Man/Kim, Nam Jae/Song, Bo Wan/Kim, Jong Woo
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Abstract
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While operating automatic tablet counter(ATC), there were filling error and filling time delay due to the breaking of tablets. This was presumed to happen mostly to uncoated tablet. This research was performed to show the adequate dosage form to operate ATC efficiently. As methods, error of stuck pills was analyzed by dosage form, distribution of dosage forms in ATC was examined in Korea and Japan. Stability was studied in terms of physical strength such as hardness and friability. The results show that 54% of stuck pills in the cassette of ATC during operation was uncoated tablet. The proportion of uncoated tablet, coated tablet, capsule in ATC was 67%, 34%, 19%, respectively in Korea, and was 9%, 64%, 26% respectively in Japan. The stability test of physical strength shows when the hardness were 1.5, 3.7, 6.6(㎏/cm2), the weight loss were 1.29%, 0.72%m 0.24% and when the friability 0.19%, 0.27%, 0.48%, the weight loss were 0.93%, 1.45%, 1.82%.
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KEYWORD
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